Amazon has published their lists of top-selling games for 2011 (digital and physical), with Call of Duty: Modern Warfare 3 winning the first place in the normal, and Deus Ex: Human Revolution making a surprise in the most digital!
Notable mention that the EA participates with 5 titles in the top-10 digital markets, a number expected to increase in 2012 as the company further promotes this way market, while impressive is the lack of Nintendo, despite the fact that the Nintendo Wii, DS and 3DS sold more than any other Gaming (portable or not).
Physical
Call of Duty: Modern Warfare 3
Just Dance 3
Elder Scrolls V: Skyrim
Battlefield 3
Batman: Arkham City
Madden NFL 12
Portal 2
Just Dance 2
Gears of War 3
FIFA Soccer 12
Digital
Deus Ex: Human Revolution
Battlefield 3
The Sims 3
Battlefield Bad Company 2
Sid Meier's Civilization V
Dead Island
Total War: Shogun 2
Call of Duty Modern Warfare 3
Crysis 2
Dragon Age 2